课题组长
 | 课题组长：李建戌，博士，副研究员 联系电话：021-37792288-665 电子邮件：lijx@cemps.ac.cn |
李建戌，2005年毕业于山东师范大学，获得理学学士学位；2012年毕业于中国科学院上海生命科学研究院植物生理生态研究所，获得理学博士学位。2012年到2015年，先后于美国加州大学伯克利分校和中国科学院植物生理生态研究所进行博士后研究。2015年11月到2023年3月在中国科学院分子植物科学卓越创新中心/植物生理生态研究所历任助理研究员、副研究员。于2023年4月加入中国科学院分子植物科学卓越创新中心辰山科研中心，担任代谢调控结构生物学组青年课题组长。曾获赛诺菲-中国科学院上海生命科学研究院优秀青年人才奖，入选中国科学院青年创新促进会会员及中国科学院特聘骨干，主持中国博士后基金面上一等资助、国家自然科学基金的青年基金和面上项目、上海市绿化和市容管理局科学技术项目等。研究方向为植物天然产物代谢与结构生物学，聚焦植物代谢物的合成及调控过程，研究关键酶的催化和分子调控机制，在Cell Research、PNAS、Progress in Lipid Research、Biochemical Journal、Plant Communications、Journal of Integrative Plant Biology和Frontiers in Plant Science等国际知名期刊发表论文25篇，申请及授权专利3项。
研究领域
利用蛋白晶体学、冷冻电镜技术、生物化学以及植物遗传及生理学等技术方法，从事植物重要代谢物（萜类、黄酮类化合物等）生物合成途径中关键酶和调控因子及其复合体的组装、催化和调控机制研究，进而进行酶工程改造及合成生物学应用。
代表性成果
代表论文（#第一作者*通讯作者）
1. Ni, Rong#; Niu, Meng#; Fu, Jie; Tan, Hui; Zhu, Tingting; Zhang, Jing; Lou, Hongxiang; Zhang, Peng; Li, Jianxu*; Cheng, Aixia*; Molecular and structural characterization of a promiscuous chalcone synthase from the fern species Stenoloma chusanum, Journal of Integrative Plant Biology, 2022, 64: 1935-1951.
2. Wang, Chengyuan#; Li, Jianxu#; Ma, Miaolian; Lin, Zhaozhu; Hu, Wenli; Lin, Wei*; Zhang, Peng*; Structural and Biochemical Insights Into Two BAHD Acyltransferases (AtSHT and AtSDT) Involved in Phenolamide Biosynthesis, Frontiers in Plant Science, 2021, 11: 610118.
3. Yao, Yuanfa#; Li, Jianxu#; Lin, Yinyan#; Zhou, Jiaqiang; Zhang, Peng*; Xu, Yingke*; Structural insights into phospholipase D function, Progress in Lipid Research, 2021, 81: 101070.
4. Niu, Meng#; Fu, Jie#; Ni, Rong; Xiong, Ruilin; Zhu, Tingting; Lou, Hongxiang; Zhang, Peng; Li, Jianxu*; Cheng Aixia*; Functional and structural investigation of chalcone synthases based on integrated metabolomics and transcriptome analysis on flavonoids and anthocyanins biosynthesis of the fern Cyclosorus parasiticus, Frontiers in Plant Science, 2021, 12: 757516.
5. Li, Jianxu#; Yu, Fang#; Guo, Hui; Xiong, Renxue; Zhang, Wenjing; He, Fangyuan; Zhang, Minhua; Zhang, Peng*; Crystal structure of plant PLDa1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D, Cell Research, 2020, 30(1): 61-69.
6. Chen, Qingwen#; Li, Jianxu#; Liu, Zhixi#; Mitsuhashi, Takaaki; Zhang, Yuting; Liu, Haili; Ma, Yihua; He, Juan; Shinada, Tetsuro; Sato, Tsutomu; Wang, Yong; Liu, Hongwei; Abe, Ikuro; Zhang, Peng*; Wang, Guodong*; Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases, Plant Communications, 2020, 1(5): 100051. (Cover story)
7. Liu, Zhifeng#; Li, Jianxu#; Sun, Yuwei#; Zhang, Peng*; Wang, Yong*; Structural Insights into the Catalytic Mechanism of a Plant Diterpene Glycosyltransferase SrUGT76G1, Plant Communications, 2020, 1(1): 100004.
8. Li, Jianxu#; Wang, Chengyuan#; Yang, Gaohua; Sun, Zhe; Guo, Hui; Shao, Kai; Gu, Yang; Jiang, Weihong*; Zhang, Peng*; Molecular mechanism of environmental D-xylose perception by a XylFII-LytS complex in bacteria, PNAS, 2017, 114(31): 8235-8240.
9. Fang, Xin#; Li, Jianxu#; Huang, Jinquan; Xiao, Youli; Zhang, Peng; Chen, Xiaoya*; Systematic identification of functional residues of Artemisia annua amorpha-4,11-diene synthase, Biochemical Journal, 2017, 474(13): 2191-2202. (Cover story)
10. Li, Jianxu#; Fang, Xin#; Zhao, Qin; Ruan, Juxin; Yang, Changqing; Wang, Lingjian; Miller, David J; Faraldos, Juan A; Allemann, Rudolf K; Chen, Xiaoya*; Zhang, Peng*; Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency, Biochemical Journal, 2013, 451(3): 417-426.
11. Song, Jiaojiao#; Fang, Xin#; Li, Chenyi; Jiang Yan; Li, Jianxu; Wu, Sheng; Guo, Juan; Liu, Yan; Fan, Hang; Huang, Yanbo; Wei, Yukun; Kong, Yu; Zhao, Qing; Xu, Jingjing; Hu, Yonghong; Chen, Xiaoya; Yang, Lei*; A 2-oxoglutarate-dependent dioxygenase converts dihydrofuran to furan in Salvia diterpenoids, Plant Physiology, 2022, 188: 1496-1506.
12. Xu, Jingjing#; Zhang, Xiaofan#; Yan, Jiang; Fan, Hang; Li, Jianxu; Li, Chenyi; Zhao, Qing; Yang, Lei; Hu, Yonghong; Martin, Cathie; Chen, Xiaoya*; A unique flavoenzyme operates in ubiquinone biosynthesis in photosynthesis-related eukaryotes, Science Advances, 2021, 7: eabl3594.
13. Chen, Qingwen; Li, Jianxu; Ma, Yihua; Yuan, Weiliang; Zhang, Peng; Wang, Guodong*; Occurrence and biosynthesis of plantsesterterpenes (C25), a new addition to terpene diversity, Plant Communications, 2021, 2: 100184.
14. Cui, Mengying; Lu, Anrui; Li, Jianxu; Liu, Jie; Fang, Yumin; Pei, Tianlin; Zhong, Xin; Wei, Yukun; Kong, Yu; Qiu, Wenqing; Hu, Yonghong; Yang, Jun; Chen, Xiaoya; Martin, Cathie; Zhao Qing*; Two types of O-methyltransferase are involved in biosynthesis of anticancer methoxylated 4’-deoxyflavones in Scutellaria baicalensis Georgi, Plant Biotechnology Journal, 2021, 20: 129-142.
15. Huang, Jinquan#; Fang, Xin#; Tian, Xiu; Chen, Ping; Lin, Jialing; Guo, Xiaoxiang; Li, Jianxu; Fan, Zhen; Song, Weimeng; Chen, Fangyan; Ahati, Ruzha; Wang, Lingjian; Zhao, Qing; Martin, Cathie; Chen, Xiaoya*; Aromatization of natural products by a specialized detoxification enzyme, Nature Chemical Biology, 2020, 16(3): 250-256.
16. Sun, Yuwei; Chen, Zhuo; Li, Jianxu; Li, Jianhua; Lv, Huajun; Yang, Jingya; Li, Weiwei; Xie, Dingan; Xiong, Zhiqiang; Zhang, Peng; Wang, Yong*; Diterpenoid UDP-Glycosyltransferases from Chinese Sweet Tea and Ashitaba Complete the Biosynthesis of Rubusoside, Molecular Plant, 2018, 11(10): 1308-1311.
申请及专利授权
1. 陈晓亚；李建戌；王凌健；洪高洁；胡文利；阮菊新；杨长青；毛颖波；一种酶活性提高的青蒿紫穗槐二烯合酶突变体及其应用，CN201110285012.X.
2. 陈晓亚；王凌健；李建戌；一种新的倍半萜合成酶及其用途， CN201210025117.6.
3. 王勇；刘志凤；孙雨伟；吕华军；张鹏；李建戌；刘海利；李建华；陈卓；糖基转移酶突变体及其应用，201910917940.X.
研究组成员
 | 马立莹 助理工程师，硕士 邮箱：2116027272@qq.com |
研究生
 | 王淞 硕士研究生 邮箱：wangsong2913@tom.com |  | 渠继苹 硕士研究生 邮箱：18206546325@163.com |